Consanguinity , Inbreeding , and Genetic Drift in Italy
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منابع مشابه
Population-genetic influences on genomic estimates of the inbreeding coefficient: a global perspective.
BACKGROUND/AIMS Culturally driven marital practices provide a key instance of an interaction between social and genetic processes in shaping patterns of human genetic variation, producing, for example, increased identity by descent through consanguineous marriage. A commonly used measure to quantify identity by descent in an individual is the inbreeding coefficient, a quantity that reflects not...
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Aims and Objectives: The objective of the present study is to assess the genetic composition of the two subgroups of Salis and the extent of genetic differentiation among them with the help of various demographic and genetic variables. Materials and Methods: A total of 520 couples belonging to two sub-groups namely, Padmasalis and Pattusalis residing in and around Visakhapatnam and Vizianagaram...
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Effective population size (Ne) is a central parameter in population and conservation genetics. It measures the magnitude of genetic drift, rates of accumulation of inbreeding in a population, and it conditions the efficacy of selection. It is often assumed that a single Ne can account for the evolution of genomes. However, recent work provides indirect evidence for heterogeneity in Ne throughou...
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A new autosomal recessive genetic condition, the SPOAN syndrome (an acronym for spastic paraplegia, optic atrophy and neuropathy syndrome), was recently discovered in an isolated region of the State of Rio Grande do Norte in Northeast Brazil, in a population that was identified by the IBGE (Brazilian Institute of Geography and Statistics) as belonging to the Brazilian communities with the highe...
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OBJECTIVE To examine mechanisms by which consanguinity might increase the risk of type 2 diabetes (T2D) in a Saudi population. METHODOLOGY 362 adult male participants were recruited, 179 were T2D patients and 183 healthy siblings. T2D severity was assessed in patients by recording age at diagnosis. In healthy subjects, diabetes risk was studied by measuring the body mass index, fasting blood ...
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